Dr. James O. Ogutu

Title/Qualifications: DR./PhD Department/Unit/Section: Medical Microbiology and Parasitology Contact Address: BOX 43844 – 00100, GPO Nairobi Position: Lecturer Area of Specialization: Medical Microbiology and Molecular Diagnostics Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Google Scholar ||  ORCID ID || Download CV

RESEARCH INTERESTS

• Mechanisms of pathogenesis of opportunistic infections in immunocompromised individuals

• Molecular multiplex diagnostic systems for detection of multiple drug resistant Gram negative bacteria from clinical sources

• Novel multiplex molecular diagnostic systems for detection of notorious hospital pathogens at the casualty, critical and/or intensive care units

• Mechanisms and trends of Probiotic activity in antibiotic-associated diarrheas

• Molecular characterization of antibiotic resistance genes

• Possible involvement of sRNAs in the regulation of β-lactamase production and activity

• Mechanisms of resistance and survival in the polymicrobe biofilms after exposure to antimicrobials

RESEARCH & PUBLICATIONS

1. Yue Gao, Qingbo Wang, Shuaifei Yang, Junhua Wu, Ming Qin, Xin Wang, Xiaona Liu, Yuting Jiang, James Ogutu, Yanhui Gao, Yanmei Yang. Interaction between fluoride exposure and bone metabolism-related gene polymorphisms in the susceptibility to essential hypertension. Ecotoxicology and Environmental Safety 2026; 311: 119903
2. Gakinya, Samuel; Nzioka, Ancent K; Mugo, Alex G; Onyuma, Timothy; Ogutu James. Autophagy-related protein LC3β and its association with clinical-pathological characteristics, mismatch repair proteins and survival in colorectal carcinoma. Frontiers in Medicine. 2025; 12: 1511227
3. Theuri M, Ndombi EM, Thamaini P, Ogutu JO, Onsongo L, Madete JK, Ofula V, Gitau S, Mwangi G, Okemo P. (2024). Clinical characteristics, anti-SARS-CoV-2 IgG titers, and inflammatory markers in individuals with post-COVID-19 condition in Kenya: a cross-sectional study. PeerJ DOI: 12:e17723 DOI 10.7717/peerj.17723      .          
4. Obulemire ER, Ogutu J, Munyoki G and Wambugu M. (2023). Perceived Quality of Health Care Provided to Mothers during Immediate Postpartum Period at Health Facilities in Kakamega County, Kenya. Texila International Journal of Public Health 11 (3): 132-146. DOI: 10.21522/TIJPH.2013.11.03.Art011.
5. Asava DN, Ochieng JO, Ogutu JO. (2022). Uptake of intrauterine contraceptive device among hiv positive women at selected health facilities in Nairobi City County, Kenya. International Academic Journal of Health, Medicine and Nursing 2 (1): 220-241.
6. Mwangi, SN, Onsongo L, Ogutu JO. (2022). Facteurs influençant la qualité de vie des proches aidants de patients Kényans atteints de cancer. Canadian Oncology Nursing Journal/Revue canadienne de soins infirmiers en oncologie 3 (24): 550-558.    
7. Kung’u, M, Onsongo L, Ogutu JO. (2022). Factors influencing quality of life among cancer survivors in Kenya. African Health Sciences 22 (4): 87-95.
8. Mwasiaji ET, Githae EN, Ogutu JO. (2022). Research direction on entrepreneurs’ mental health and wellbeing for global sustainability agenda. International Academic Journal of Innovation, Leadership and Entrepreneurship    2 (2): 339-356.
9.  Kung’u M, Onsongo L, Ogutu JO. (2021). Impact of Social Support on Quality of Life of Cancer Patients in Kenya. International Journal of Innovative Research and Development 10 (9): 172-177. DOI: 10.24940/ijird/2021/v10/i9/SEP21041.
10. Obora, Maximillar; Onsongo, Lister; Ogutu, James O. Determinants of sexual function among survivors of gynaecological cancers in a tertiary hospital: a cross-sectional study. Ecancer medicalscience. 2022; 16
11. Mwangi, Samuel N; Onsongo, Lister; Ogutu, James O. Factors effecting quality of life for family caregivers of cancer patients in Kenya. Canadian Oncology Nursing Journal. 2022; 324: 550-558
12. Asava, Diana Navalya; Ochieng, James Otieno; Ogutu, James O. Uptake of intrauterine contraceptive device among HIV positive women at selected health facilities in Nairobi City County, Kenya. International Academic Journal of Health, Medicine and Nursing . 2022; 21: 220-241
13. Gikonyo, Catherine W; Onsongo, L; Ogutu, JO. Professional Quality of Life among Nurses Caring for Cancer Patients. Public Health Nursing. 2021; 4: 13-29
14. Rapando, Japheth Wambani; Ngugi, Mathew Piero; Muturi, Margaret; Ogutu, James Opiyo. Phytochemical Composition and Antibacterial Activities of the Ethyl Acetate Leaf Extract of Ocimum basilicum. Researchsquare 2020
15. Mwasiaji ET, Jagongo AO, Ogutu JO. Coronavirus Disease Outbreak and the Supply Chain of Selected Small and Medium Manufacturing Enterprises in Kenya. International Journal of Business and Social Science. 2020; 11(4): 7-15 doi:10.30845/ijbss.v11n4p2
16. Wenli Zhang, Ying Zhang, Xinxin Wang, Fengshu Ding, Yingmei Fu, Jizi Zhao, Wuqi Song, Ogutu James Opiyo and Fengmin Zhang. Siderophores in clinical isolates of Klebsiella pneumoniae promote ciprofloxacin resistance by inhibiting oxidative stress. Biochemical and Biophysical Research Communication doi: 10.1016/j.bbrc.2017.04.108. [Epub ahead of print]
17. Zhao J, Chen J, Zhao M, Qiu X, Chen X, Zhang W, Sun R, James Opiyo Ogutu, Zhang F. Multilocus sequence types and virulence determinants of hypermucoviscosity-positive Klebsiella pneumoniae isolated from community-acquired infection cases in Harbin, North China. Japanese Journal of Infectious Diseases.2016; 69: 357-360
18. Jing Wu, Aimei Li, Yujun Li, Xiaoguang Li, Qingmeng Zhang, Wuqi Song, Yao Wang, James O. Ogutu, Jindong Wang, Jianbo Li, Renkuan Tang , Fengmin Zhang. Chlorpromazine inhibits mitochondrial apoptotic pathway via increasing expression of tissue factor. The International Journal of Biochemistry & Cell Biology. 2015; 70: 82-91
19. James O. Ogutu, Qingmeng Zhang, Ying Huang, Huo Yan, Lijie Su, Bo Gao, Wenli Zhang, Jizi Zhao, Wenhui Cai, Wenjing Li, Hong Zhao, Yang Chen, Wuqi Song, Xiaobei Chen, Yingmei Fu, Fengmin Zhang. Development of a multiplex PCR system and its application in the detection of blaSHV, blaTEM, blaCTX-M-1, blaCTX-M-9 and blaOXA-1 group genes in clinical Klebsiella pneumoniae and Escherichia coli strains. Journal of Antibiotics. 2015; 68: 725-733
20. Ying Huang, James O. Ogutu, Gu J, Ding F, You Yu, Zhao H, Li W, Zhang Z, Zhang W, Chen X, Fu Y, Zhang F. Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults. BioMed Research International. Doi:1155/2015/168292 [Epub ahead of print]
21. James O. Ogutu. Antimicrobial resistance in human health. Editorial. The East and Central Africa Medical Journal. 2015; 2:59

22. Ying Huang, James O. Ogutu, Jiarui Gu, Fengshu Ding, Yuhong You, Yan Huo, Hong Zhao, WenjingLi, ZhiweiZhang, Wenli Zhang, XiaobeiChen, Yingmei Fu, and Fengmin Zhang. Comparative Analysis of Quinolone Resistance in Clinical Isolates of Klebsiella pneumoniae and Escherichia coli from Chinese Children and Adults. BioMed Research International. Volume 2015, Article ID 168292, 6 pages http://dx.doi.org/10.1155/2015/168292 

Conference/Workshops/Seminar Papers
Conference Papers

Presented a paper titled “MDR Escherichia coli isolated from chicken: a potential source of MDR infections in man.” at the International Conference on Infectious Disease Prevention and Control held at Harbin Medical University on 28 th –29 th December, 2018.

Other Publications
1. Patent Title: 产超广谱B-内酰胺酶肺炎克雷伯菌耐药性及基因分型” (New group- specific multiplex PCR primer set for rapid detection of β-lactamase (bla) genes). Inventors: Zhang Fengmin, James O. Ogutu, Song Wuqi, Fu Yingmei, Zhang Wenli and Cai Wenhui. Patent number: CN 104293925B Applicant: Harbin Medical University. Date of approval: 2016-04-27.
2. I was an Editor of the Conference Proceedings for the International Reproductive Health Conference, organized by the School of Public Health, Kenyatta University in 2017.

Funded Projects
1. March 2021 to December 2024 – COVID-19 Africa Rapid Grant Fund by the Nation Research Foundation, South Africa – I am a Co-Investigator in this multi-institution collaborative project titled: “Uptake of preventive measures, sero-surveillance and complementary management of COVID-19 in Kenya.” (KES 10,000,000).
2. July to August 2018 – Carnegie African Diaspora Fellowship Programme Grant by the International Institute of Education, Washington DC USA to conduct studies on Type 2 Diabetes Mellitus (KES 1,500,000).
3. July 2016 – National Commission for Science, Technology and Innovation (NACOSTI) PhD Research Grant (KES 1,137,150).

Conferenced/Workshops/Seminars Attended
Workshops Attended
1. February to August 2022 – SMLD Training Programme Covering several topics on related to leadership by Christ Is The Answer Ministries Clay City Assembly.
2. October 3 rd 2018 – Leadership and Strategy Development Workshop organized by Collaboration for Entrepreneurial Universities at Kenyatta University.
3. May 9 th -11 th 2018 – Participated in a training on Risk Assessment Techniques by OneSource Africa organized by the Directorate of QMS&PC, Kenyatta University.
4. January 9 th 2018 – Training on the Role of the Chairpersons of Departments on the Implementation of University Policy organized by the administration Division, Kenyatta University.
5. October 28 th -30 th 2017 – Training on Beyond Management to Leadership: A Transformative Leadership Programme organized by Africa Centre for Transformative and Inclusive Leadership (ACTIL) and Kenyatta Universities and held at Kenyatta University Conference Centre.